NZ_CM000441.1	RefSeq	region	1	4094363		+		ID=NZ_CM000441.1:1..4094363;Dbxref=taxon:455631;Is_circular=true;Name=ANONYMOUS;country=Canada: Quebec;gb-synonym=Clostridium difficile QCD-66c26;gbkey=Src;genome=chromosome;isolate=QCD-66c26;isolation-source=patient with severe CDAD;mol_type=genomic DNA;nat-host=Homo sapiens;note=binary toxin positive%3B tcdC delta-117 and 18bp deletion;old-name=Clostridium difficile QCD-66c26
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	157759	158016		+		locus_tag=ctg1_157;transl_table=11;translation=MRKHSDCMNFCAVDATKGICRLSKQMINLDDSACPEIKVMPKCKNCKNFVEANDEGIGKCVGLEKEDWVYSTLNAITCEGHVFNE
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	protocluster	157759	176925		+		aStool=rule-based-clusters;category=RiPP;contig_edge=False;core_location=[166866:168288];cutoff=10000;detection_rule=minimum(1%2C [Bottromycin_Methyltransferase_RRE%2C Cyanobactin_D_RRE%2C Cytolysin_C_RRE%2C Goadsporin_CD_RRE%2C Heterocycloanthracin_C_RRE%2C Lanthipeptide_LanB_RRE%2C Lasso_Fused_RRE%2C Mycofactocin_RRE%2C NHLP_CD_RRE%2C Other_Sactipeptide_rSAM_RRE%2C Pantocin_Microcin_RRE%2C Plantazolicin_C_RRE%2C PlpY_RRE%2C PqqD_RRE%2C Proteusin_Epimerase_RRE%2C Proteusin_Methyltransferase_RRE%2C Quinohemoprotein_rSAM_RRE%2C Ranthipeptide_rSAM_RRE%2C Stand_Alone_Lasso_RRE%2C Streptide_RRE%2C Subtilosin_rSAM_RRE%2C Thiaglutamate_B_RRE%2C Thiaglutamate_G_RRE%2C Thiaglutamate_I_RRE%2C Thiopeptide_F_RRE%2C Thuricin_rSAM_RRE%2C Thurincin_rSAM_RRE%2C Trifolitoxin_RRE]);neighbourhood=10000;product=RRE-containing;protocluster_number=1;tool=antismash
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	proto_core	166867	168288		+		aStool=rule-based-clusters;tool=antismash;cutoff=10000;detection_rule=minimum(1%2C [Bottromycin_Methyltransferase_RRE%2C Cyanobactin_D_RRE%2C Cytolysin_C_RRE%2C Goadsporin_CD_RRE%2C Heterocycloanthracin_C_RRE%2C Lanthipeptide_LanB_RRE%2C Lasso_Fused_RRE%2C Mycofactocin_RRE%2C NHLP_CD_RRE%2C Other_Sactipeptide_rSAM_RRE%2C Pantocin_Microcin_RRE%2C Plantazolicin_C_RRE%2C PlpY_RRE%2C PqqD_RRE%2C Proteusin_Epimerase_RRE%2C Proteusin_Methyltransferase_RRE%2C Quinohemoprotein_rSAM_RRE%2C Ranthipeptide_rSAM_RRE%2C Stand_Alone_Lasso_RRE%2C Streptide_RRE%2C Subtilosin_rSAM_RRE%2C Thiaglutamate_B_RRE%2C Thiaglutamate_G_RRE%2C Thiaglutamate_I_RRE%2C Thiopeptide_F_RRE%2C Thuricin_rSAM_RRE%2C Thurincin_rSAM_RRE%2C Trifolitoxin_RRE]);neighbourhood=10000;product=RRE-containing;protocluster_number=1
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	antismash_cand_cluster	157759	176925		+		candidate_cluster_number=1;contig_edge=False;detection_rules=minimum(1%2C [Bottromycin_Methyltransferase_RRE%2C Cyanobactin_D_RRE%2C Cytolysin_C_RRE%2C Goadsporin_CD_RRE%2C Heterocycloanthracin_C_RRE%2C Lanthipeptide_LanB_RRE%2C Lasso_Fused_RRE%2C Mycofactocin_RRE%2C NHLP_CD_RRE%2C Other_Sactipeptide_rSAM_RRE%2C Pantocin_Microcin_RRE%2C Plantazolicin_C_RRE%2C PlpY_RRE%2C PqqD_RRE%2C Proteusin_Epimerase_RRE%2C Proteusin_Methyltransferase_RRE%2C Quinohemoprotein_rSAM_RRE%2C Ranthipeptide_rSAM_RRE%2C Stand_Alone_Lasso_RRE%2C Streptide_RRE%2C Subtilosin_rSAM_RRE%2C Thiaglutamate_B_RRE%2C Thiaglutamate_G_RRE%2C Thiaglutamate_I_RRE%2C Thiopeptide_F_RRE%2C Thuricin_rSAM_RRE%2C Thurincin_rSAM_RRE%2C Trifolitoxin_RRE]);kind=single;product=RRE-containing;protoclusters=1;tool=antismash
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	antismash_region	157759	176925		+		candidate_cluster_numbers=1;contig_edge=False;product=RRE-containing;region_number=1;rules=minimum(1%2C [Bottromycin_Methyltransferase_RRE%2C Cyanobactin_D_RRE%2C Cytolysin_C_RRE%2C Goadsporin_CD_RRE%2C Heterocycloanthracin_C_RRE%2C Lanthipeptide_LanB_RRE%2C Lasso_Fused_RRE%2C Mycofactocin_RRE%2C NHLP_CD_RRE%2C Other_Sactipeptide_rSAM_RRE%2C Pantocin_Microcin_RRE%2C Plantazolicin_C_RRE%2C PlpY_RRE%2C PqqD_RRE%2C Proteusin_Epimerase_RRE%2C Proteusin_Methyltransferase_RRE%2C Quinohemoprotein_rSAM_RRE%2C Ranthipeptide_rSAM_RRE%2C Stand_Alone_Lasso_RRE%2C Streptide_RRE%2C Subtilosin_rSAM_RRE%2C Thiaglutamate_B_RRE%2C Thiaglutamate_G_RRE%2C Thiaglutamate_I_RRE%2C Thiopeptide_F_RRE%2C Thuricin_rSAM_RRE%2C Thurincin_rSAM_RRE%2C Trifolitoxin_RRE]);tool=antismash
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	158009	158959		+		gene_functions=biosynthetic-additional (rule-based-clusters) Fer4_12,biosynthetic-additional (rule-based-clusters) PF04055;gene_kind=biosynthetic-additional;locus_tag=ctg1_158;sec_met_domain=Fer4_12 (E-value: 3.8e-14%2C bitscore: 50.9%2C seeds: 127%2C tool: rule-based-clusters),PF04055 (E-value: 3.5e-19%2C bitscore: 67.5%2C seeds: 159%2C tool: rule-based-clusters);transl_table=11;translation=MSSQKQLEGMIFDVQSFSVHDGPGCRTTVFLNGCPLSCKWCANPESWTVRPHMMFSELSCQYENGCTVCHGKCKNGALSFNLDNKPVIDWNICKDCESFECVNSCYYNAFKLCAKPYTVDELVQVIKRDSNNWRSNGGVTFSGGEPLLQHEFLHEVLLKCHEVNIHTAIETSACVSNEVFNKIFKDIDFAFIDIKHMDREKHKEQTGVYNDLILENISNLANSDWNGRLVLRVPVISGFNDSAENISDIISFMHKNNLIEINLLPFHRLGESKWIQLGKEYEYSDKGDIDEEHLEELQDIFLDNGIACYVGHETAF
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	159279	160241		+		gene_functions=biosynthetic-additional (rule-based-clusters) Abi;gene_kind=biosynthetic-additional;locus_tag=ctg1_159;sec_met_domain=Abi (E-value: 6.3e-17%2C bitscore: 59.5%2C seeds: 91%2C tool: rule-based-clusters);transl_table=11;translation=MNKSWSNLIIKNKDKKVRSGWIIITVMAAFYIFEYYLSTILMEIIRKILIATGDINLKTNYFSEYANWLNDVGLQVVFQILTDSLMIIIPIIVWRFIMKNPISEMGLHSYRIKKKEGYVGMLLGIFNCTVIFIITITIGGGHVTSWVPKISPLTVSWILVFILVAFAEEILNRGFFMAVLRRCKNIYFIMIVPSVIFGLIHIWNPDVTFLSVINIIIIGILFSYMFIKSSNIWMCIGYHFTWNVFQGIIYGMPVSGLQVPGIITTQITHGNLLNGGMFGIEGGILTTFVNLLSFIFVWYYYRDSKYDFVSDKVNVTNIKN
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	160340	161320		-		gene_functions=biosynthetic-additional (rule-based-clusters) Abi;gene_kind=biosynthetic-additional;locus_tag=ctg1_160;sec_met_domain=Abi (E-value: 1.4e-11%2C bitscore: 42.4%2C seeds: 91%2C tool: rule-based-clusters);transl_table=11;translation=MNLKLIWINILNPVFIKNEIKRKKIQIIIFFFINFGLTYSLGLLLYYNKFIDPENFASFMMILPLSSVAIAKFYTEGLNNDMYEFYSLIILFFLIYSLLIVLKLLNLINNNEFIIINLILTFISSLSIIIYSSNKKNLYPVKNIKLGSLLIIYFMISVIVPTSFILILQGAQPNYSGIIKFIFTPITSLTTIYIFFSEEYAWRGFLQNIFFDKFGKKLGVIILGMCWSLWHLPLIFTLYTPEAPILGVILRSIHIVGISIFLGYLYIKTKNIWFCAIIHVLNNSAFLITNSKESTITYHDILIVSMVVLIFYVPFLFTKEYKNNLE
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	162448	162915		+		locus_tag=ctg1_161;transl_table=11;translation=MKFLNVLIVVEDIEKSKKFYYDILGLKVICDFGENVVLEGNISLQEKKLWLEFINKSDSEVKFNGNDAELYFEEDNFDTFVERLSTMKGIDYVHLAIEHRWGQRAIRFYDLDGHIIEIGETMSSVCRRFLDSGLSIDEVAKRMDVTVEYIESVLE
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	164087	164800		+		locus_tag=ctg1_162;transl_table=11;translation=MINIIICEGKKSERVILNDYINTFFYNYNFEYNIKEFENGGDLLKKYPNNVDIIFMDIDLNDENGFNVSKEIKKFDESVRIIFVSSSNKYIKKGYEIGVYRYLEKPLKYSLFKEAISSYLKECYKNEAILSIKCKCKIYFIKVDDILYLEVLKNDLTIHTEKGIYTFKNSMKEIESNLEEHNFFRCHKSYLINLMKVNMLDIENNIVFINQNSIIVSRYKIKLLREKLNSCLVDVII
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	165073	166845		+		gene_functions=transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 149.2%3B E-value: 2.5e-45);gene_kind=transport;locus_tag=ctg1_163;transl_table=11;translation=VENGKFQFFKGVRNCFNMIYLHDKRYLFISMFMAIFQGIVPSISLLVSQNIINNMQTFSKSVKEILVLLIMYLIINIIPSIFQSFYGYYRIKFNKNFEKHIETMMLEKSLTLSLKDFEDDNTYDMINRAQSQKGFNITILSENLISIIRESVSTLSLIVVLSQFQLWLIIVVIVIPVLKSLYSIKLGKEQYDVSVNRTWKERKAWYIDYLLSKGYAYKEIMVFRIGSKLINHYKKLKEDIISQDMNIAKKNFIATLLCTVLDSIVSAGIIGFIIIQGILKKILIGDATTYIQAVQSIKDNVESIFSLFSSVIQDLFYTDLLFKFLDYNCKEDSIEHIKIFEKIGDINKIELINISYKYNHSSEYSLKNINLTLNKNDPIAILGKNGSGKTTLLKILLGFYDDYEGDILINGKNLKDIEKDEYIRKVSCMFQDYIKYEATLKENVAMGDVYKSNLEEKVKSKLKETKLKPSIYEEDGLETILGTWFGKKQLSMGEWQKVAISRTLMKDADMYIFDEPDSSLDSEAGNELLSLYKKTFENKIGIFITHHIQHAKKITNNIVVLENGKLLESGRHDELMDKKGVYFNLFCNCK
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	166867	168288		+		gene_functions=biosynthetic (rule-based-clusters) RRE-containing: Other_Sactipeptide_rSAM_RRE,biosynthetic-additional (rule-based-clusters) PF04055,biosynthetic-additional (rule-based-clusters) Fer4_12;gene_kind=biosynthetic;locus_tag=ctg1_164;sec_met_domain=Other_Sactipeptide_rSAM_RRE (E-value: 1.7e-16%2C bitscore: 58.2%2C seeds: 133%2C tool: rule-based-clusters),PF04055 (E-value: 5.8e-14%2C bitscore: 50.6%2C seeds: 157%2C tool: rule-based-clusters),Fer4_12 (E-value: 1.1e-07%2C bitscore: 29.9%2C seeds: 110%2C tool: rule-based-clusters);transl_table=11;translation=MNQKPFIHTFKAGKSYFIYDVNTDKILKVNAAVYNYLNKIEHNLEKESDWNIEIEDEINTLINYGFLKNKRVNKTMHPETKYIKYHIENNLSSIILQVTQNCNLRCDYCIYSGSYSNRVHTNKRMNIDVAKRSIDYLIKNSSQLNEVSVGFYGGEPLLEFDLIKQIVEYVKVVGEGKEIYFNLTTNATLFNEEIIEFFVKNNITTMISLDGGKEIHDKSRKFANTGEGSHDVVLKNVRYIKNKYPEYYKKNITFNTVINSENDYISIDDFISKNETLKDSNFLASTLNNNYSDKEIVSSDEYILGKSYDRFLTLLNKLKFIKDESMSPLSRIERALLDDFRYEKNIEGRLELPDVWHHGGPCIPGAFRIFVTTDGEFFPCERVSESSKMGMIGNLDSGVDIEKAEKLLNIGKLYEEQCSDCWAYSYCDICIAKIDDTKCNENEIKPHDCDRIRHSTENNMKDYCVLKSLGYQY
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	168317	169387		+		locus_tag=ctg1_165;transl_table=11;translation=MEKVLIYPFNYNFFTILNHCNKISDIEINSLVSPSGWGLCNKEYNVNNIITKVTNDFQSELKKNSLVWFVDSKENLDLEKFIIPKLKVALKEGKKILYTRDDLNKISRYISHYEFKKINEWNLEKYEIRDIEGISQINTPIIFICGLYGGLDTFDVNIRIGEELRKRGFSILQFGPKKESYLFKMIPIPEFMFDDSISSKTKIINFNHFIKDKEVEAKPDLIIIEVPGELFPFSRKMVGNFGIRAFEISNAVINDCGILCIPSSIYDREYCEELKYFIKGRHGINIDYFSIEKKVIDTYETEVKQKFSYMSLDENFFVEDIEDYEKTFFIHDNKQLLELVDNIVNQLKEYAKVISI
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	169403	169654		+		locus_tag=ctg1_166;transl_table=11;translation=MNYTEKELLLENIFFDVTGINFNKNNNLKKELFFSPSLHIQPRELLLVFCEVIENFNIKIPEEKLLNRQFTSFDNVLKIINMV
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	169705	169908		+		locus_tag=ctg1_167;transl_table=11;translation=MSFGKRIEMNNIGVETRGVCTIMCPYTCKMMASSSCNCKNNDYNARGGSYNTYYNKLIHGQRTPDGM
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	170392	170685		+		locus_tag=ctg1_168;transl_table=11;translation=MISMIMMLIGVLFIVFGIILTAVEIKGKMPGFYGVGQNAVRKNAIGIIAAGIALIFFRNGLDSIDSILTYGVFLVIELVVIGLYFLIRIKYDKDGNL
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	170817	172166		-		gene_functions=biosynthetic-additional (smcogs) SMCOG1038:phenylalanine-specific permease (Score: 241.8%3B E-value: 1.7e-73);gene_kind=biosynthetic-additional;locus_tag=ctg1_169;transl_table=11;translation=MEKAKKLGLFSMILLGINSIIGSGIFLLPGKVYSLAGQNSMFIYIFATLLVLSILLCFAEVGSMFDKNGGAYLYSKKAFGDFIGFEVGTMSWFIRIISWSTLAVGFATALGSFWPESATEYKGCIAAILVTLLSINSLFGIKSTKIMNNVITIAKLVPLIVFVIVGIFFIKFVNIVPSGNVVNSSMGPAIILVFYAFTGFESFIVASGEMENPKKNLPIALITTIFICAIIYILIQIVCMGILGDRLFENSIPIADASSVFLGNYGKVFISVATLISIFGINIGSSIVTPKCGSSLAEEGSLPAFIGKTNKYGAPYVAIIISLICCIPLVLTGSFEQLAVMSVIARFAQYIPTCLSVIVLRKRTDVKASFKIPFGPVIPMVAILGSLWLLQQAWAEDISKPITQNRVLIGLGAMLLIAPLYIFMKKNKEIEHKNKSEDSKLYISREKIQ
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	172203	173423		-		gene_functions=biosynthetic-additional (smcogs) SMCOG1244:amidohydrolase (Score: 417.5%3B E-value: 7.3e-127);gene_kind=biosynthetic-additional;locus_tag=ctg1_170;transl_table=11;translation=MQQALKLKYQTKELGKDFVIESCNSIKPWLINIRRELHKIPELALEENLTKQKVISYLKEIGIDYMEFTKHNGIMAYILKESADKTICIRADMDALPIEEENNIPYKSIHSGKMHACGHDAHTTMLLGACKVLHSIKDKLNVNVKFLFQPAEEGFGGAKFLVEDGCLENPKADYIFGLHVMPHIETGLIETKYDTLNASVDTIKISIKGKRAHGAYPENGIDAIVTASQIVTSLQTIISRNLEPNNAAVLTIGKIYGGDAHNVICEDVKLEGTLRTLNSKTRNFMIDKIAKIVGDTASAFGCVGTLHVSDENYPAVINEKELVDTVISSTKELLGEEKFILRPNPSLGGEDFSFYTEHCKGAFFHLGCKNEEKGLISPLHTSSFNIDEDCLPIGVMMHVMNTLYFN
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	173792	175804		-		gene_functions=regulatory (smcogs) SMCOG1112:sigma-54 dependent trancsriptional regulator (Score: 348%3B E-value: 1.5e-105);gene_kind=regulatory;locus_tag=ctg1_171;transl_table=11;translation=MKKSVALVNDSRKDLIDFLENNLKLVFGDSININRYFINEINDNDIINDDVILVMSVERLDKIINNILDKKKVIVVRRTFREDKIYNLLSLPQGTNALIVNDSDETTLETISLFYKIGVTNIRPIPYMNDNNYKNIKIAITPGVPEKVPSFISDIFDLGHRYIDISTFIEIINLLQIDSKEIQSNLVKYSEEIISLDTGIKDKYKELFLKIEELDTILNLSKDGILFTSKDGEINTYNSKVKDILDINEDIYGKYIDDIFVDSLKVLLSEKEILDKVVVFNKKYINVNKKNIYNRDEKMGTYYSLQEITYIKKLEQNLTKKLREKGQIAKYTFKDIKTNSPKMFECIDLAKKVSKSDLSILIRGESGTGKELIAQSIHNNSNRKNQPFIAVNCAAVPENLLESQLFGYDKGTFTGGLKDGKQGLFELANNGTIFLDEIGDMPLELQTKLLRVLQEKQIMPVGSHNVINIDVRIISATNKNLEQMIDNSQFREDLYYRLNTIPINIPPLRERKEDILIIMEDLINKKLVITPEAKKLIQNYMWKGNIRELQNVTSYLNIMCEDIVLEKDLPPNLRSSDNKNTSLKLKYSKNDILNILEILILNKESDVGIGRGLILKALLDKNLQITEGKIKKIFEYLKKEELIICSSGRYGSKITQKGEDFYNKLKYKGL
NZ_CM000441.1	antiSMASHv7.0.0beta1-67b538a9	CDS	176275	176925		+		locus_tag=ctg1_172;transl_table=11;translation=MKAEKTSIYPIIKNNLNKISIVEYKKGQRFVASDKDLQEVFFIIEGVALVECTTRGGNKFLVDIVPENEFIGKISYIYEHNLKCDIFAKTNIKLFRFEKNVFEEFYLKPDFIALFHRKCTRRIYELYKTRMVRELFSCTEVIAYCISNKQENNVCNIKAIRNFSEIYSISRKSRYHSLLKLTEKEIVKKMGNTYEILNYDELHKLAFEVKEFLEDE