Comparative and pangenomic analysis of the genus Streptomyces
Streptomycetes are highly metabolically gifted bacteria with the abilities to produce bioproducts that have profound economic and societal importance. These
bioproducts are produced by metabolic pathways including those for the biosynthesis of secondary metabolites and catabolism of plant biomass constituents.
Advancements in genome sequencing technologies have revealed a wealth of untapped metabolic potential from Streptomyces genomes. Here, we report the largest
Streptomyces pangenome generated by using 205 complete genomes. Metabolic potentials of the pangenome and individual genomes were analyzed, revealing degrees of
conservation of individual metabolic pathways and strains potentially suitable for metabolic engineering. Of them, Streptomyces bingchenggensis was identified as
a potent degrader of plant biomass. Polyketide, non-ribosomal peptide, and gamma-butyrolactone biosynthetic enzymes are primarily strain specific while ectoine
and some terpene biosynthetic pathways are highly conserved. A large number of transcription factors associated with secondary metabolism are strain-specific
while those controlling basic biological processes are highly conserved. Although the majority of genes involved in morphological development are highly conserved,
there are strain-specific varieties which may contribute to fine tuning the timing of cellular differentiation. Overall, these results provide insights into the
metabolic potential, regulation and physiology of streptomycetes, which will facilitate further exploitation of these important bacteria.
(DOI: https://doi.org/10.1038/s41598-022-21731-1)
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Pan_strep_genome_v2.tar.gz | 1.4 gB |
SMC BGC Sequences, October 2023
Gzip compressed database of the nucleotides and proteins of the biosynthetic gene clusters from SMC.
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smc_blast-20231025.fasta.gz | 67 gB |
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smc_blastp-20231025.faa.gz | 45 gB |
